The focus of our group is upon the enzymes involved in bacterial cell wall biosynthesis, which continues to be a validated target for the development of new antimicrobial compounds and strategies. } else { Kawai, Fumihiro, Clarke, Thomas B., Roper, David I., Han, Gab-Jo, Hwang, Kwang Yeon, Unzai, Satoru, Obayashi, Eiji, Park, Sam-Yong, Tame, Jeremy R. H. Sova, Matej, Cadez, Gasper, Turk, Samo, Majce, Vita, Polanc, Slovenko, Batson, Sarah, Lloyd, Adrian, Roper, David I., Fishwick, Colin W. G., Gobec, Stanislav, Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Mok, B. James, Caddick, Stephen, Roper, David I., Dowson, Christopher G., Bugg, Tim. See Photos. Disclaimer: AAAS and EurekAlert! x.parentNode.insertBefore(s, x); 3.
David Roper. Email: life dot sciences at warwick dot ac dot uk Tel: +44 (0)24 765 74251
Turner, Daniel J., Portman, Ian, Dafforn, Tim, Rodger, Alison, Roper, David I., Smith, Corinne J., Turner, Matthew S. Bugg, Tim, Braddick, Darren, Dowson, Christopher G., Roper, David I. Hattersley, John G., Pérez-Velázquez, J., Chappell, M. J. Please let us know if you agree to functional, advertising and performance cookies. Lysenko, Elena S., Clarke, Thomas B., Shchepetov, Mikhail, Ratner, Adam J., Roper, David I., Dowson, Christopher G., Weiser, Jeffrey N. Lee, Sarah C., Stoilova-Mcphie, Svetla, Baxter, Laura, Fülöp, Vilmos, Henderson, Janey, Rodger, Alison, Roper, David I., Scott, David J., Smith, Corinne J., Morgan, J. Alun W. Izumi, Atsushi, Rea, Dean, Adachi, Tomoko, Unzai, Satoru, Park, Sam-Yong, Roper, David I., Tame, Jeremy R. H. Rea, Dean, Fülöp, Vilmos, Bugg, Tim, Roper, David I. Kishida, H., Unzai, Satoru, Roper, David I., Lloyd, A, Park, S.Y., Tame, Jeremy R. H. Adachi, Tomoko, Izumi, Atsushi, Rea, Dean, Park, Sam-Yong, Tame, Jeremy R. H., Roper, David I. Acta Crystallographica Section F-Structural Biology And Crystallization Communicati, Tötemeyer, Sabine, Sheppard, Mark, Lloyd, Adrian, Roper, David I., Dowson, Christopher G., Underhill, David, Murray, Peter, Maskell, Duncan, Bryant, Clare. (Mr Souvik Naskar), BBSRC FTMA Investigating the potential to exploit the mechanism of by which tRNA-dependent amino acid synthetases activate cognate and non-cognate amino acids as a strategy for future antibiotic development (Ricky Cain), Accelerate CHNUK AMR discovery: Establishing and exploiting a joint China/UK platform to enable high throughput fragment based inhibitor discovery, 17 Alert bid led by Nottingham: A new multi-wavelength analytical ultracentrifuge for the study of biomeolcular interactions, 5th Midlands Molecular Microbiology Meeting, Multi-Targetting of tRNA synthetases: A paradigm shift in combating AMR, Molecular Dissection of PASTA domains from Enterococci (Researcher Mobility Grant for Christopher Thoroughgood), Centre for integrative theoretical and experimental analytical science for application to bacterial cell division and Quality by Design (CAS-IDP), Team CanUK: Novel antibacterial targets, assays, probes and opportunities in bacterial cell wall biogenesis, BBSRC Link with Astra Zeneca:Reagents and assays to exploit the final steps of peptidoglycan construction, The biochemical characterisation of pivotal enzymes involved in mycobacterial peptidoglycan biosynthesis Birmingham-Warwick PG grant, (led by UCL) BBSRC project Disruption of cytoplasmic membrane-associated functions in staphylococcus aureus by epicatechin gallate led by School of Pharmacy (with Sheffield and Birmingham), Subproject for Institution # 33323 - RCHAR3009 - A new Raman instrument for polarized spectroscopy of biomacromolecular systems, A new Raman instrument for polarized spectroscopy of biomacromolecular systems. offers eligible public information officers paid access to a reliable news release distribution service. The Roper group uses structural biology techniques, principally X-ray structural determination, in combination with molecular biology and biochemical approaches, to investigate the molecular basis of microbial physiology in relation to antibiotic resistance and bacterial cell wall (peptidoglycan) biosynthesis in Gram-positive and Gram-negative pathogens. Unesco- loreal Visiting Fellowship for Vita Majce, Structure and Biology of Membrane Proteins, MAR Imaging plate x ray data collection system, UK - BaCWAN: UK-Bacterial Cell Wall Assembly Network, Exploration and Exploitation of the Enzymology of PBP Driven Peptidoglycan Biosynthesis to Discover Novel Non-beta Lactam Antibiotics, Towards a complete structure-function description of an aromatic degradative pathway, Molecular Physiology and structural analysis of the innate immune system triggered by bacterial cell wall components, Structure, Stability & Molecular Interactions In Biological Systems. David Roper. You can update your cookie preferences at any time. 2. His research encompasses fundamental and translation approaches including assay development and drug discovery approach. })(); School of Life Sciences, Gibbet Hill Campus, The University of Warwick, Coventry, CV4 7AL David Roper. In addition, his research group also uses a synthetic and systems biology approaches to obtain and reengineer pathway intermediates as chemical probes, substrates and inhibitors. Email: life dot sciences at warwick dot ac dot uk Tel: +44 (0)24 765 74251 See Photos. BSc Biochemistry, University College Cardiff 1987 PhD Biochemistry, University of Leicester 1990 MRC Career Development Fellowship, 1996-2000. 44-782-454-0863 EurekAlert! MRC Career Development Fellowship, 1996-2000, University of Warwick Lecturer in Structural Biology 2001-2006, University of Warwick Associate Professor of Structural Biology 2006-2014, University of Warwick Reader in Structural Biology 2014-2017, University of Warwick BBSRC-RSE Enterprise Fellow 2015-2016, University of Warwick Professor of Structural Biology 2017-present. Usha, Veeraraghavan, Dover, Lynn G., Roper, David I., Lloyd, Adrian J., Besra, Gurdyal S. University of Warwick.
Chemistry. See Photos. View David Roper’s profile on LinkedIn, the world's largest professional community. David Roper. Find your friends on Facebook.
Tran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng Ruh, Linington, Roger G., Mahapatra, Sebabrata, Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Tim, Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J., Payne, Richard J. Calvez, Philippe, Breukink, Eefjan, Roper, David I., Dib, Mélanie, Contreras-Martel, Carlos, Zapun, André. Usha, Veeraraghavan, Dover, Lynn G., Roper, David I., Besra, Gurdyal S. Lloyd, Adrian J., Gilbey, Andrea M., Blewett, Anne M., De Pascale, Gianfranco, El Zoeiby, Ahmed, Levesque, Roger C., Catherwood, Anita C., Tomasz, Alexander, Bugg, Tim, Roper, David I., Dowson, Christopher G. Rea, Dean, Hovington, Rebecca, Rakus, John F., Gerlt, John A., Fülöp, Vilmos, Bugg, Tim, Roper, David I. Alderwick, Luke J., Dover, Lynn G., Veerapen, Natacha, Gurcha, Sudagar S., Kremer, Laurent, Roper, David I., Pathak, Ashish K., Reynolds, Robert C., Besra, Gurdyal S. De Pascale, Gianfranco, Lloyd, Adrian J., Schouten, James A., Gilbey, Andrea M., Roper, David I., Dowson, Christopher G., Bugg, Tim, Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Roper, David I., Dowson, Christopher G., Bugg, Tim. We also have a synthetic facility for the provision of peptidoglycan intermediates to the scientific and pharma community see www.warwick.ac.uk/go/bacwan for details. 1: Aminoacyl-tRNA synthetases Bacterial Cell Wall Biosynthesis This approach not only allows novel insight to the biology underpinning these pathways but also enables biotechnological exploration and exploitation. Warwick Crop Centre is located on our Wellesbourne campus. David Roper. Scott Group, life dot sciences at warwick dot ac dot uk, Coronavirus (Covid-19): Latest updates and information, The extracellular domain of two-component system sensor kinase VanS from streptomyces coelicolor binds Vancomycin at a newly identified binding site, Substrate and stereochemical control of peptidoglycan cross-linking by transpeptidation by Escherichia coli PBP1B, Insights into intrinsic resistance and bacterial cell division from a structure of EnvC bound to the FtsX periplasmic domain, Bacterial lipid II analogs : novel in vitro substrates for mammalian oligosaccharyl diphosphodolichol diphosphatase (DLODP) activities, Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase, Nano-encapsulated escherichia coli divisome anchor ZipA, and in complex with FtsZ, SMA-PAGE : a new method to examine complexes of membrane proteins using SMALP nano-encapsulation and native gel electrophoresis, Metallohelices that kill Gram-negative pathogens using intracellular antimicrobial peptide pathways, Mechanisms of incorporation for D-amino acid probes that target peptidoglycan biosynthesis, The role of the jaw subdomain of peptidoglycan glycosyltransferases for lipid II polymerization, The crystal structure and oligomeric form of Escherichia coli L,D-carboxypeptidase A, A road map for prioritizing warheads for cysteine targeting covalent inhibitors, In silico identification, synthesis and biological evaluation of novel tetrazole inhibitors of MurB, Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis, Substitutions in PBP2b from ß-lactam resistant Streptococcus pneumoniae have different effects on enzymatic activity and drug reactivity, Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis, Inhibition of D-Ala : D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine, In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA).
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